Article
Class II-restricted T cell receptor engineered in vitro for higher affinity retains peptide specificity and function.
Proceedings of the National Academy of Sciences of the United States of America - 27 Dec 2005
Weber K Scott, Donermeyer David L, Allen Paul M, Kranz David M
Abstract excerpt
The T cell receptor (TCR) alphabeta heterodimer determines the peptide and MHC specificity of a T cell. It has been proposed that in vivo selection processes maintain low TCR affinities because T cells with higher-affinity TCRs would (i) have reduced functional capacity or (ii) cross-react with self-peptides resulting in clonal deletion. We used the class II-restricted T cell clone 3.L2, specific for murine...
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