Article
MHC genotype controls the capacity of ligand density to switch T helper (Th)-1/Th-2 priming in vivo.
Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 1996
Schountz T, Kasselman J P, Martinson F A, Brown L, Murray J S
Abstract excerpt
A quantitative mechanism for the differentiation of CD4 T cells into recognized subsets of Th1 and Th2 effectors is controversial. Here, we define the Ag dose more precisely to the density of a minimal immunogenic peptide presented on the surface of a specific APC type. Th1 and Th2 responder MHC...
Topics
- Animals
- Antigen Presentation
- Antigens, CD
- B7-2 Antigen
- Cell Differentiation
- Dose-Response Relationship, Immunologic
- Fibroblasts
- Genotype
- H-2 Antigens
- Histocompatibility Antigens Class II
- Immunologic Memory
- Ligands
- Lymphocyte Activation
- Major Histocompatibility Complex
- Membrane Glycoproteins
- Mice
- Mice, Inbred A
- Peptide Fragments