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Article

MHC genotype controls the capacity of ligand density to switch T helper (Th)-1/Th-2 priming in vivo.

Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 1996

Schountz T, Kasselman J P, Martinson F A, Brown L, Murray J S

Abstract excerpt

A quantitative mechanism for the differentiation of CD4 T cells into recognized subsets of Th1 and Th2 effectors is controversial. Here, we define the Ag dose more precisely to the density of a minimal immunogenic peptide presented on the surface of a specific APC type. Th1 and Th2 responder MHC genotypes differ by as much as an order of magnitude in the density of this peptide displayed on B7-2+ B cells. We...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 8892620

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APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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MHC genotype controls the capacity of ligand density to switch T helper (Th)-1/Th-2 priming in vivo.PMID 8892620Read ↗

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