Article
Peptide-major histocompatibility complex class II complexes with mixed agonist/antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signaling.
The Journal of experimental medicine - 1 Apr 1993
Racioppi L, Ronchese F, Matis L A, Germain R N
Abstract excerpt
Clonal activation of CD4+ and CD8+ T lymphocytes depends on binding of peptide-major histocompatibility complex (MHC) molecule complexes by their alpha/beta receptors, eventually resulting in sufficient aggregation to initiate second messenger generation. The nature of intracellular signals resul...
Topics
- Amino Acid Sequence
- Animals
- Clone Cells
- Cytochrome c Group
- Histocompatibility Antigens Class II
- Interleukin-2
- Interleukin-3
- L Cells
- Ligands
- Mice
- Molecular Sequence Data
- Mutation
- Receptors, Antigen, T-Cell
- Signal Transduction
- T-Lymphocytes