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Article

CD8 coreceptor-mediated focusing can reorder the agonist hierarchy of peptide ligands recognized via the T cell receptor.

Proceedings of the National Academy of Sciences of the United States of America - 20 Jul 2021

Clement Mathew, Knezevic Lea, Dockree Tamsin, McLaren James E, Ladell Kristin, Miners Kelly L, Llewellyn-Lacey Sian, Rubina Anzelika, Francis Ore, Cole David K, Sewell Andrew K, Bridgeman John S, Price David A, van den Berg Hugo A, Wooldridge Linda

Abstract excerpt

CD8+ T cells are inherently cross-reactive and recognize numerous peptide antigens in the context of a given major histocompatibility complex class I (MHCI) molecule via the clonotypically expressed T cell receptor (TCR). The lineally expressed coreceptor CD8 interacts coordinately with MHCI at a distinct and largely invariant site to slow the TCR/peptide-MHCI (pMHCI) dissociation rate and enhance antigen...

Read the complete abstract on PubMed

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Share to Antigens
Share to CD8 Antigens

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to CD8-Positive T-Lymphocytes

Share to Cross Reactions

Share to Histocompatibility Antigens Class I

Share to Lymphocyte Activation

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Share to Receptors, Antigen, T-Cell

Source

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Identifiers

PMID: 34272276
DOI: 10.1073/pnas.2019639118
PMCID: PMC8307375

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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