Article
Class I negative CD8 T cells reveal the confounding role of peptide-transfer onto CD8 T cells stimulated with soluble H2-Kb molecules.
Proceedings of the National Academy of Sciences of the United States of America - 15 Oct 2002
Schott Eckart, Bertho Nicolas, Ge Qing, Maurice Madelon M, Ploegh Hidde L
Abstract excerpt
Crosslinking of the T cell receptor has been proposed to be a prerequisite for T cell activation. Although the evidence supports this notion for CD4 T cells, the situation for CD8 T cells is less clear. Soluble class I monomers have been used to determine activation requirements in vitro with contradictory results. The possibility of transfer of peptide from soluble class I molecules onto class I molecules...
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