Article
High-density presentation of an immunodominant minimal peptide on B cells is MHC-linked to Th1-like immunity.
Cellular immunology - 1 Nov 1995
Murray J S, Kasselman J P, Schountz T
Abstract excerpt
Ligand-directed differences in the amount of peptide presented on a specific APC subset could influence the functional outcome of any given immune response. We have investigated this issue with a biochemically determined immunodominant peptide that is presented at a higher density on the APC of Th1 responders (I-As genotypes) than on the APC of Th2 responders (I-Ab genotypes). MHC-linked high peptide density is...
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