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Article

Association between the functional variant of the catechol-O-methyltransferase (COMT) gene and type 1 alcoholism.

Molecular psychiatry - 1 May 1999

Tiihonen J, Hallikainen T, Lachman H, Saito T, Volavka J, Kauhanen J, Salonen J T, Ryynänen O P, Koulu M, Karvonen M K, Pohjalainen T, Syvälahti E, Hietala J

Abstract excerpt

Catechol-O-methyltransferase (COMT) is an enzyme which has a crucial role in the metabolism of dopamine. It has been suggested that a common functional genetic polymorphism in the COMT gene, which results in 3 to 4-fold difference in COMT enzyme activity, may contribute to the etiology of mental disorders such as bipolar disorder and alcoholism. Since ethanol-induced euphoria is associated with the rapid release...

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Identifiers

PMID: 10395222
DOI: 10.1038/sj.mp.4000509

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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