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Article

Association study between high and low activity polymorphism of catechol-O-methyltransferase gene and alcoholism

1 Sept 1999

Abstract excerpt

Catechol-O-methyltransferase (COMT) is a key modulator of dopaminergic and noradrenergic neurotransmission. There is a functional polymorphism of the COMT gene, Val108Met in the soluble form of the enzyme (Val158Met in the membrane-bound form). Involvement of the dopaminergic systems in alcoholism has been suggested in mice and humans. We examined associations between this polymorphism and alcoholism in 175...

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PMID: 10551543
DOI: 10.1097/00041444-199909000-00004

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