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Article

Preliminary evidence of an association between bipolar disorder in females and the catechol-O-methyltransferase gene.

Psychiatric genetics - 1 Jan 1998

Mynett-Johnson L A, Murphy V E, Claffey E, Shields D C, McKeon P

Abstract excerpt

Catechol-O-methyltransferase (COMT) catalyses the methylation, and hence the inactivation, of catecholamines including the neurotransmitters dopamine and noradrenaline. There is evidence implicating COMT as a candidate gene for a number of neuropsychiatric conditions including bipolar disorder. A...

Topics

Alleles
Bipolar Disorder
Case-Control Studies
Catechol O-Methyltransferase
Chromosomes, Human, Pair 22
Female
Genetic Predisposition to Disease
Genotype
Haplotypes
Humans
Ireland
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Parents

Polymerase Chain Reaction

Polymorphism, Genetic

Polymorphism, Restriction Fragment Length

Risk

Source

Identifiers

PMID: 9861640
DOI: 10.1097/00041444-199808040-00004

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9861640-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Preliminary evidence of an association between bipolar disorder in females and the catechol-O-methyltransferase gene.PMID 9861640Read ↗

No association between bipolar disorder and alleles at a functional polymorphism in the COMT gene. Biomed European Bipolar Collaborative Group.Semantic proximity Read ↗

Association analysis of the catechol O-methyltransferase gene and bipolar affective disorder.Semantic proximity Read ↗

The catechol-O-methyl transferase (COMT) gene as a candidate for psychiatric phenotypes: evidence and lessons.Semantic proximity Read ↗

Potential role of membrane-bound COMT gene polymorphisms in female depression vulnerability.Semantic proximity Read ↗

COMT: a common susceptibility gene in bipolar disorder and schizophrenia.Semantic proximity Read ↗

A potential interaction between COMT and MTHFR genetic variants in Han Chinese patients with bipolar II disorder.Semantic proximity Read ↗

Association study of candidate variants of COMT with neuroticism, anxiety and depression.Semantic proximity Read ↗

Low activity allele of catechol-o-methyltransferase gene and Japanese unipolar depression.Semantic proximity Read ↗

Catechol-O-methyltransferase (COMT): a gene contributing to sex differences in brain function, and to sexual dimorphism in the predisposition to psychiatric disorders.Semantic proximity Read ↗

Low activity allele of catechol-O-methyltransferase gene associated with rapid cycling bipolar disorder.Semantic proximity Read ↗

Association of the functional V158M catechol-O-methyl-transferase polymorphism with panic disorder in women.Semantic proximity Read ↗

Family-based and case-control study of catechol-O-methyltransferase in schizophrenia among Palestinian Arabs.Semantic proximity Read ↗

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