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Article

Preliminary evidence of an association between bipolar disorder in females and the catechol-O-methyltransferase gene.

Psychiatric genetics - 1 Jan 1998

Mynett-Johnson L A, Murphy V E, Claffey E, Shields D C, McKeon P

Abstract excerpt

Catechol-O-methyltransferase (COMT) catalyses the methylation, and hence the inactivation, of catecholamines including the neurotransmitters dopamine and noradrenaline. There is evidence implicating COMT as a candidate gene for a number of neuropsychiatric conditions including bipolar disorder. A long recognized population variation in COMT activity exists and it has recently been established that variation in...

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Source

Identifiers

PMID: 9861640
DOI: 10.1097/00041444-199808040-00004

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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Preliminary evidence of an association between bipolar disorder in females and the catechol-O-methyltransferase gene.PMID 9861640Read ↗

No association between bipolar disorder and alleles at a functional polymorphism in the COMT gene. Biomed European Bipolar Collaborative Group.Semantic proximity Read ↗

Association analysis of the catechol O-methyltransferase gene and bipolar affective disorder.Semantic proximity Read ↗

The catechol-O-methyl transferase (COMT) gene as a candidate for psychiatric phenotypes: evidence and lessons.Semantic proximity Read ↗

Potential role of membrane-bound COMT gene polymorphisms in female depression vulnerability.Semantic proximity Read ↗

COMT: a common susceptibility gene in bipolar disorder and schizophrenia.Semantic proximity Read ↗

A potential interaction between COMT and MTHFR genetic variants in Han Chinese patients with bipolar II disorder.Semantic proximity Read ↗

Association study of candidate variants of COMT with neuroticism, anxiety and depression.Semantic proximity Read ↗

Low activity allele of catechol-o-methyltransferase gene and Japanese unipolar depression.Semantic proximity Read ↗

Catechol-O-methyltransferase (COMT): a gene contributing to sex differences in brain function, and to sexual dimorphism in the predisposition to psychiatric disorders.Semantic proximity Read ↗

Low activity allele of catechol-O-methyltransferase gene associated with rapid cycling bipolar disorder.Semantic proximity Read ↗

Association of the functional V158M catechol-O-methyl-transferase polymorphism with panic disorder in women.Semantic proximity Read ↗

Family-based and case-control study of catechol-O-methyltransferase in schizophrenia among Palestinian Arabs.Semantic proximity Read ↗

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