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Article

Association between the functional polymorphism of catechol-O-methyltransferase gene and alcohol consumption among social drinkers.

Alcoholism, clinical and experimental research - 1 Feb 2000

Kauhanen J, Hallikainen T, Tuomainen T P, Koulu M, Karvonen M K, Salonen J T, Tiihonen J

Abstract excerpt

BACKGROUND: A common functional genetic polymorphism in the catechol-O-methyltransferase (COMT) gene (Val158 Met) results in 3- to 4-fold differences in COMT enzyme activity and dopamine inactivation rate. Previous studies have shown that type I alcoholism is more common among subjects with low activity COMT genotype (LL), compared with high activity (HH) or heterozygotic (LH) genotypes. METHODS: We studied...

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Source

Identifiers

PMID: 10698363

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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