Pharmacogenetics of catechol-O-methyltransferase: frequency of low activity allele in a Ghanaian population.

doi:10.1002/1098-1004(200011)16:5<445::AID-HUMU13>3.0.CO;2-3

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Article

Pharmacogenetics of catechol-O-methyltransferase: frequency of low activity allele in a Ghanaian population.

Human mutation - 1 Nov 2000

Ameyaw M M, Syvänen A C, Ulmanen I, Ofori-Adjei D, McLeod H L

Abstract excerpt

Catechol-O-methyltransferase (COMT) catalyses the O-methylation of neurotransmitters, catechol hormones and drugs such as levodopa and methyldopa. Ethnic differences in COMT activity have been observed in several populations. Previous studies suggest that the g1947G>A low activity allele is less common in individuals of African origin. COMT genotyping was performed using a mini-sequencing method in 195 healthy...

Topics

Adolescent
Adult
Alleles
Asia, Western
Catechol O-Methyltransferase
Enzyme Activation
Female
Gene Frequency
Ghana
Humans
Kenya
Levodopa
Male
Methyldopa
Middle Aged

Source

Open in PubMed

Identifiers

PMID: 11058906
DOI: 10.1002/1098-1004(200011)16:5<445::AID-HUMU13>3.0.CO;2-3

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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