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Article

Low activity allele of catechol-o-methyltransferase gene and Japanese unipolar depression.

Neuroreport - 11 May 1998

Ohara K, Nagai M, Suzuki Y, Ohara K

Abstract excerpt

Several studies have shown that depressed patients have significantly lower catechol-o-methyltransferase (COMT) activity than healthy controls. Two COMT genes coding for low activity, COMTL, and high activity, COMTH have been identified. We undertook an association study on 75 depressive disorder patients, 40 bipolar disorder patients and 135 healthy controls. All the subjects were Japanese. Patients with...

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Source

Identifiers

PMID: 9631418
DOI: 10.1097/00001756-199805110-00009

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Low activity allele of catechol-o-methyltransferase gene and Japanese unipolar depression.PMID 9631418Read ↗

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Association analysis of the catechol O-methyltransferase gene and bipolar affective disorder.Semantic proximity Read ↗

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Association study of a functional catechol-O-methyltransferase gene polymorphism in Japanese schizophrenics.Semantic proximity Read ↗

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High and low activity alleles of catechol-O-methyltransferase gene: ethnic difference and possible association with Parkinson's disease.Semantic proximity Read ↗

Association study of Catechol-O-Methyltransferase (COMT) rs4680 Val158Met gene polymorphism and suicide attempt in Mexican adolescents with major depressive disorder.Semantic proximity Read ↗

In Silico Prediction of the Effects of Nonsynonymous Single Nucleotide Polymorphisms in the Human Catechol-O-Methyltransferase (COMT) Gene.Semantic proximity Read ↗

Catechol-O-methyltransferase Val158Met polymorphism: frequency analysis in Han Chinese subjects and allelic association of the low activity allele with bipolar affective disorder.Semantic proximity Read ↗

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