Low activity allele of catechol-o-methyltransferase gene and Japanese unipolar depression.

doi:10.1097/00001756-199805110-00009

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Article

Low activity allele of catechol-o-methyltransferase gene and Japanese unipolar depression.

Neuroreport - 11 May 1998

Ohara K, Nagai M, Suzuki Y, Ohara K

Abstract excerpt

Several studies have shown that depressed patients have significantly lower catechol-o-methyltransferase (COMT) activity than healthy controls. Two COMT genes coding for low activity, COMTL, and high activity, COMTH have been identified. We undertook an association study on 75 depressive disorder...

Topics

Adult
Age of Onset
Alleles
Bipolar Disorder
Catechol O-Methyltransferase
Depressive Disorder
Dysthymic Disorder
Female
Genotype
Humans
Japan
Male
Middle Aged
Polymerase Chain Reaction
Polymorphism, Genetic
Reference Values
Suicide, Attempted

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