Article
Association between a catechol-o-methyltransferase polymorphism and obsessive-compulsive disorder in the Afrikaner population.
Journal of affective disorders - 1 Jun 2001
Niehaus D J, Kinnear C J, Corfield V A, du Toit P L, van Kradenburg J, Moolman-Smook J C, Weyers J B, Potgieter A, Seedat S, Emsley R A, Knowles J A, Brink P A, Stein D J
Abstract excerpt
BACKGROUND: It has been proposed that the catechol-o-methyl transferase gene (COMT) may play a role in the pathogenesis of obsessive-compulsive disorder (OCD). Whereas studies in a North American population showed that the low activity (L) allele of a functional polymorphism in COMT was associated with OCD in male patients, this result was not supported by studies in a Japanese population. The present association...
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