Article
Cdkn2a encodes functional variation of p16INK4a but not p19ARF, which confers selection in mouse lung tumorigenesis.
Molecular carcinogenesis - 1 Jun 1999
Herzog C R, Noh S, Lantry L E, Guan K L, You M
Abstract excerpt
The cyclin-dependent kinase inhibitor 2a (Cdkn2a) locus encodes two distinct tumor suppressors, p16INK4a and p19ARF, whose functions interrelate in the regulation of cell proliferation as key components of the retinoblastoma and p53 pathways, respectively. In many types of cancer, alterations of Cdkn2a abrogate the functions of both suppressors, implying that both are integral to the genesis of certain cancer...
Topics
- Adenocarcinoma
- Animals
- Cell Transformation, Neoplastic
- Cyclin-Dependent Kinase Inhibitor p16
- Humans
- Jurkat Cells
- Lung Neoplasms
- Mice
- Mutation
- Polymorphism, Single-Stranded Conformational
- Proteins