Article
Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest.
Cell - 15 Dec 1995
Quelle D E, Zindy F, Ashmun R A, Sherr C J
Abstract excerpt
The INK4a (MTS1, CDKN2) gene encodes an inhibitor (p16INK4a) of the cyclin D-dependent kinases CDK4 and CDK6 that blocks them from phosphorylating the retinoblastoma protein (pRB) and prevents exit from the G1 phase of the cell cycle. Deletions and mutations involving INK4a occur frequently in ca...
Topics
- 3T3 Cells
- Amino Acid Sequence
- Animals
- Base Sequence
- Carrier Proteins
- Cell Cycle
- Cell Nucleus
- Cloning, Molecular
- Cyclin-Dependent Kinase Inhibitor p16
- Exons
- Genes, Tumor Suppressor
- Humans
- Mice
- Molecular Sequence Data
- Mutation
- Organ Specificity
- Protein Biosynthesis
- Proteins