Article
Germline control of somatic Kras mutations in mouse lung tumors.
Molecular carcinogenesis - 1 Jun 2018
Borrego Andrea, Cabrera Wafa H K, Jensen José R, Correa Mara, Ribeiro Orlando G, Starobinas Nancy, De Franco Marcelo, Pettinicchio Angela, Dragani Tommaso A, Ibañez Olga C M, Manenti Giacomo
Abstract excerpt
Somatic KRAS mutations are common in human lung adenocarcinomas and are associated with worse prognosis. In mice, Kras is frequently mutated in both spontaneous and experimentally induced lung tumors, although the pattern of mutation varies among strains, suggesting that such mutations are not random events. We tested if the occurrence of Kras mutations is under genetic control in two mouse intercrosses. Codon 61...
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