Article
Inactivation of both Rb and p53 pathways in mouse lung epithelial cell lines.
Experimental lung research - 1 Jan 2000
McDoniels-Silvers A L, Herzog C R, Tyson F L, Malkinson A M, You M
Abstract excerpt
Aberrant expression of key cell cycle regulatory genes is essential for the immortalization and transformation of cells in vitro. We examined 20 mouse lung epithelial cell lines (2 nontumorigenic, 5 nonmetastatic, and 13 metastatic) for mutations or alterations in the expression of key components of the Rb pathway (pRb and p16INK4a) and the p53 pathway (p53 and p19ARF). Seven cell lines had a mutation in exons 5...
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