Role of tumor suppressor genes in transplacental lung carcinogenesis.

doi:10.1002/(sici)1098-2744(199803)21:3<177::aid-mc5>3.0.co;2-j

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Article

Role of tumor suppressor genes in transplacental lung carcinogenesis.

Molecular carcinogenesis - 1 Mar 1998

Rollins L A, Leone-Kabler S, O'Sullivan M G, Miller M S

Abstract excerpt

Most human cancers involve multiple genetic changes, including activation of oncogenes such as Ki-ras-2 (Kras2) and inactivation of any one of a number of tumor suppressor genes such as p53 and members of the retinoblastoma (Rb) regulatory axis. As part of an ongoing project to determine how in u...

Topics

Adenocarcinoma
Animals
Carcinogens
Cyclin-Dependent Kinase Inhibitor p16
Exons
Female
Genes, Retinoblastoma
Genes, Tumor Suppressor
Genes, p53
Genes, ras
Introns
Lung Neoplasms
Male
Methylcholanthrene
Mice
Mice, Inbred C57BL
Mice, Inbred DBA
Mutation

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