Article
Role of tumor suppressor genes in transplacental lung carcinogenesis.
Molecular carcinogenesis - 1 Mar 1998
Rollins L A, Leone-Kabler S, O'Sullivan M G, Miller M S
Abstract excerpt
Most human cancers involve multiple genetic changes, including activation of oncogenes such as Ki-ras-2 (Kras2) and inactivation of any one of a number of tumor suppressor genes such as p53 and members of the retinoblastoma (Rb) regulatory axis. As part of an ongoing project to determine how in utero exposure to chemical carcinogens affects the molecular pathogenesis of murine lung tumors, the p53 and p16Cdkn2a...
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