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Article

Predisposition to lung tumorigenesis.

Toxicology letters - 15 Mar 2000

Manenti G, Nomoto T, De Gregorio L, Gariboldi M, Stefania Falvella F, Nagao M, Dragani T A

Abstract excerpt

Mouse inbred strains with inherited predisposition and resistance to lung cancer provide an essential tool for the dissection of the genetics of this complex disease. We have previously mapped a major locus (Pulmonary adenoma susceptibility 1, Pas1) affecting inherited predisposition to lung cancer in mice on chromosome 6, near Kras2. Appropriate crosses that include susceptible mice (Pas1(s)) provide a model...

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Identifiers

PMID: 10720740
DOI: 10.1016/s0378-4274(99)00232-5

Genes

PTHLH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Predisposition to lung tumorigenesis.PMID 10720740Read ↗

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Population-based mapping of pulmonary adenoma susceptibility 1 locus.Semantic proximity Read ↗

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Mouse pulmonary adenoma susceptibility 1 locus is an expression QTL modulating Kras-4A.Semantic proximity Read ↗

Localization of a human lung adenocarcinoma susceptibility locus, possibly syntenic to the mouse Pas1 locus, in the vicinity of the D12S1034 locus on chromosome 12p11.2-p12.1.Semantic proximity Read ↗

A functional switch from lung cancer resistance to susceptibility at the Pas1 locus in Kras2LA2 mice.Semantic proximity Read ↗

Positional cloning of the major quantitative trait locus underlying lung tumor susceptibility in mice.Semantic proximity Read ↗

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Fine mapping and candidate gene analyses of pulmonary adenoma resistance 1, a major genetic determinant of mouse lung adenoma resistance.Semantic proximity Read ↗

Outbred CD-1 mice carry the susceptibility allele at the pulmonary adenoma susceptibility 1 (Pas1) locus.Semantic proximity Read ↗

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