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Article

Haploinsufficiency of p18(INK4c) sensitizes mice to carcinogen-induced tumorigenesis.

Molecular and cellular biology - 1 Feb 2003

Bai Feng, Pei Xin-Hai, Godfrey Virginia L, Xiong Yue

Abstract excerpt

The INK4 family of cyclin-dependent kinase (CDK) inhibitors negatively regulates cyclin D-dependent CDK4 and CDK6 and thereby retains the growth-suppressive function of Rb family proteins. Mutations in the CDK4 gene conferring INK4 resistance are associated with familial and sporadic melanoma in humans and result in a wide spectrum of tumors in mice. Whereas loss of function of other INK4 genes in mice leads to...

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Source

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Identifiers

PMID: 12556487
DOI: 10.1128/MCB.23.4.1269-1277.2003
PMCID: PMC141153

Genes

CDK4
CDK6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Haploinsufficiency of p18(INK4c) sensitizes mice to carcinogen-induced tumorigenesis.PMID 12556487Read ↗

Genetic evidence for functional dependency of p18Ink4c on Cdk4.Semantic proximity Read ↗

Cooperation between Cdk4 and p27kip1 in tumor development: a preclinical model to evaluate cell cycle inhibitors with therapeutic activity.Semantic proximity Read ↗

Wide spectrum of tumors in knock-in mice carrying a Cdk4 protein insensitive to INK4 inhibitors.Semantic proximity Read ↗

<i>INK4d</i>-Deficient Mice Are Fertile Despite Testicular AtrophySemantic proximity Read ↗

Differential roles of Rad18 in repressing carcinogen- and oncogene-driven mutagenesis <i>in vivo</i>Semantic proximity Read ↗

Invasive melanoma in Cdk4-targeted mice.Semantic proximity Read ↗

p18<sup><i>Ink4c</i></sup> and <i>Pten</i> Constrain a Positive Regulatory Loop between Cell Growth and Cell Cycle ControlSemantic proximity Read ↗

Role of the INK4a locus in tumor suppression and cell mortality.Semantic proximity Read ↗

Identification of p18 INK4c as a tumor suppressor gene in glioblastoma multiforme.Semantic proximity Read ↗

Distinct versus redundant properties among members of the INK4 family of cyclin‐dependent kinase inhibitorsSemantic proximity Read ↗

p18Ink4c, but not p27Kip1, collaborates with Men1 to suppress neuroendocrine organ tumors.Semantic proximity Read ↗

Expression of p16Ink4a Compensates for <i>p18Ink4c</i> Loss in Cyclin-Dependent Kinase 4/6–Dependent Tumors and TissuesSemantic proximity Read ↗

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