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Article

Multidrug-resistant phenotype influences the differentiation of a human colon carcinoma cell line.

Biochemical and biophysical research communications - 27 May 1999

Rimet O, Mirrione A, Barra Y

Abstract excerpt

The human colon carcinoma cell line HT29-D4, which constitutively expresses a very low level of the MDR1 gene product, was made multidrug resistant by transfection with a human MDR1 cDNA from the pHaMDR1/A expression vector and selection by colchicine. Resistant clones were 3- to 15-fold resistant to colchicine and were cross-resistant to doxorubicin (3- to 4-fold). MDR1 gene expression was associated with the...

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Identifiers

PMID: 10334913
DOI: 10.1006/bbrc.1999.0711

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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