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Article

Mechanism of multidrug resistance in human tumour cell lines and complete reversion of cellular resistance.

European journal of cancer (Oxford, England : 1990) - 1 Jan 1992

Boiocchi M, Toffoli G

Abstract excerpt

The biochemical basis of the multidrug-resistant (MDR) phenotype has been investigated in drug-resistant sublines derived from LoVo and SW984 human colon carcinoma cell lines by doxorubicin selection. Besides drug extrusion through the plasma membrane, two further observations, both ascribable to...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 1
Biological Transport
Carcinoma
Cisplatin
Colonic Neoplasms
Dactinomycin
Doxorubicin
Drug Resistance
Gene Expression
Humans
Membrane Glycoproteins
Neoplasm Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

RNA, Messenger

Tumor Cells, Cultured

Vincristine

Source

Identifiers

PMID: 1352696
DOI: 10.1016/0959-8049(92)90465-e

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1352696-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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