Article
Expression of the mdr1 gene in human colorectal carcinomas: relationship with multidrug resistance inferred from analysis of human colorectal carcinoma cell lines.
Cancer chemotherapy and pharmacology - 1 Jan 1992
Toffoli G, Viel A, Tumiotto L, Maestro R, Biscontin G, Boiocchi M
Abstract excerpt
To investigate whether mdr1 gene products are involved in conferring the chemoresistant phenotype to human colorectal carcinomas (HCCs), we determined the mdr1 mRNA expression level (mdr1 EL) in surgical specimens from 29 pharmacologically untreated patients and analyzed the relationship between mdr1 EL and drug resistance in an in vitro experimental model. This consisted of 7 HCC cell lines chosen to cover the...
Topics
- Antineoplastic Agents
- Cisplatin
- Colorectal Neoplasms
- DNA Probes
- Dactinomycin
- Dose-Response Relationship, Drug
- Doxorubicin
- Drug Resistance
- Gene Expression Regulation, Neoplastic
- Humans