Article
Biological characterization of multidrug-resistant human colon carcinoma sublines induced/selected by two methods.
Cancer research - 1 Jun 1990
Yang L Y, Trujillo J M
Abstract excerpt
Two independent multidrug-resistant (MDR) sublines, AdR1.2 and SRA1.2, were developed from the established human colon carcinoma cell line LoVo. AdR1.2 was developed by a long-term continuous exposure of LoVo cells to Adriamycin in stepwise increments of concentration; SRA1.2 was selected/induced by pulse treatments by using a single concentration of Adriamycin. The two resistant sublines were cross-resistant and...
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