Article
Pleiotropic, multidrug-resistant phenotype and P-glycoprotein: a review.
Chemotherapy - 1 Jan 1992
Ban T
Abstract excerpt
This article is a brief review of recent knowledge about the pleiotropic resistant phenotype--multidrug-resistant (MDR) phenotype--which is responsible for cross-resistance in cancer chemotherapy. Thus it is possible to explain chemoresistance to vinca alkaloids, podophyllotoxins and anthracyclines. The MDR phenotype is associated with reduced intracellular drug accumulation by drug efflux, utilizing...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Antineoplastic Agents
- Drug Resistance
- Humans
- Membrane Glycoproteins
- Neoplasms
- Phenotype