Differential expression of sphingolipids in MRP1 overexpressing HT29 cells

doi:10.1002/1097-0215(20000715)87:2<172::aid-ijc3>3.0.co;2-k

Article

Differential expression of sphingolipids in MRP1 overexpressing HT29 cells

1 Jan 2000

Abstract excerpt

We have obtained a novel multidrug resistant cell line, derived from HT29 G(+) human colon carcinoma cells, by selection with gradually increasing concentrations of the anti-mitotic, microtubule-disrupting agent colchicine. This HT29(col) cell line displayed a 25-fold increase in colchicine resistance and exhibited cross-resistance to doxorubicin, VP16, vincristine and taxol. Immunoblotting, combined with RT-PCR...

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