Article
Colchicine-resistance and enhancement of P-glycoprotein activity after co-cultivation of drug-sensitive cells with multidrug resistant variants.
Cell biology international - 1 Feb 1995
Eliseenkova A V, Kakpakova E S, Abdrjashitov R I, Stavrovskaya A A
Abstract excerpt
The role of cellular interactions in the resistance of Djungurian hamster cells to colchicine (CH) and in the efficiency of P-glycoprotein function was studied. Mixtures of CH-resistant and CH-sensitive cells as well as control unmixed cells were propagated for 3 days and the sensitivity of the c...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Animals
- Cell Line
- Colchicine
- Cricetinae
- Drug Resistance
- Drug Resistance, Multiple
- Fibroblasts
- Flow Cytometry
- Genetic Variation
- Hypoxanthine Phosphoribosyltransferase
- Sensitivity and Specificity