Multidrug resistance phenotype of human BRO melanoma cells transfected with a wild-type human mdr1 complementary DNA.

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Article

Multidrug resistance phenotype of human BRO melanoma cells transfected with a wild-type human mdr1 complementary DNA.

Cancer research - 15 Mar 1990

Lincke C R, van der Bliek A M, Schuurhuis G J, van der Velde-Koerts T, Smit J J, Borst P

Abstract excerpt

We have transfected a eukaryotic expression vector containing a mdr1 complementary DNA isolated from normal human liver into human BRO melanoma cells to study the drug-resistant phenotype produced by the exclusive overexpression of normal human mdr1 P-glycoprotein. The drug resistance pattern of mdr1-transfected clones includes relatively high resistance to gramicidin D (about 300-fold), vincristine (about...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 1
Antineoplastic Agents
Biological Transport
Cell Division
Cell Line
Cell Membrane
DNA
Daunorubicin
Drug Resistance
Humans
Kinetics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Melanoma

Membrane Glycoproteins

Nucleic Acid Hybridization

Phenotype

Transfection

Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 1968359

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1968359-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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