Pleiotropic-resistant phenotype is a multifactorial phenomenon in human colon carcinoma cell lines.

doi:10.1038/bjc.1991.11

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Article

Pleiotropic-resistant phenotype is a multifactorial phenomenon in human colon carcinoma cell lines.

British journal of cancer - 1 Jan 1991

Toffoli G, Viel A, Tumiotto L, Biscontin G, Rossi C, Boiocchi M

Abstract excerpt

The biochemical basis of multidrug-resistant (MDR) phenotype has been investigated in drug-resistant sublines independently obtained in our laboratories by single step doxorubicin (DOX) selection of LoVo, DLD1, and SW948 human colon carcinoma (HCC) cell lines. All the chemoresistant sublines have been found to be cross-resistant to DOX, actinomycin-D (ACT-D) and vincristine (VCR) but not to...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 1
Cell Division
Cell Membrane
Cisplatin
Colonic Neoplasms
Dactinomycin
Doxorubicin
Drug Resistance
Extracellular Space
Gene Expression
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Intracellular Fluid

Kinetics

Membrane Glycoproteins

Phenotype

RNA, Messenger

Transcription, Genetic

Tumor Cells, Cultured

Source

Open in PubMed Open full text

Identifiers

PMID: 1671208
DOI: 10.1038/bjc.1991.11
PMCID: PMC1971628

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1671208-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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