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Article

Specific reversal of MDR1/P-gp-dependent multidrug resistance by RNA interference in colon cancer cells

1 Jan 1994

Abstract excerpt

No control cell line was available for previous RNA interference studies on reversal of multidrug resistance (MDR) in colon cancer cells. Here, human COLO 320DM, with HT-29 as the control, colon cancer cell lines were used to investigate the reversal of MDR1/P-gp-dependent MDR by siRNA (#4123 and #4029 MDR1 siRNAs) targeting to MDR1 mRNA. Both siRNAs inhibited expression of MDR1 and P-gp in COLO 320DM. The...

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Identifiers

PMID: 19020725
DOI: 10.3892/or_00000163

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