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Article

Acquisition of the H19 methylation imprint occurs differentially on the parental alleles during spermatogenesis.

Genomics - 15 May 1999

Davis T L, Trasler J M, Moss S B, Yang G J, Bartolomei M S

Abstract excerpt

The imprinted mouse H19 gene is hypomethylated on the expressed maternal allele and hypermethylated on the silent paternal allele. A 2-kb region of differential methylation located from -2 to -4 kb relative to the H19 transcriptional start site has been proposed to act as the imprinting mark since hypermethylation in this region is inherited from sperm and retained on the paternal allele throughout development....

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Identifiers

PMID: 10331941
DOI: 10.1006/geno.1999.5813

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Acquisition of the H19 methylation imprint occurs differentially on the parental alleles during spermatogenesis.PMID 10331941Read ↗

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