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Article

Temporal and spatial regulation of H19 imprinting in normal and uniparental mouse embryos

1 Dec 1995

Abstract excerpt

The mouse H19 gene is imprinted so that the paternal copy is both methylated and repressed during fetal development. However, the CpG-rich promoter region encompassing the transcription start is not methylated in sperm; this region must therefore become methylated postzygotically. We first examined the timing of DNA methylation of this region and the corresponding expression of H19. Both parental copies are...

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Share to Epigenetics and DNA Methylation
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Identifiers

PMID: 8575319
DOI: 10.1242/dev.121.12.4195

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Temporal and spatial regulation of H19 imprinting in normal and uniparental mouse embryosPMID 8575319Read ↗

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