Article
Developmental control of allelic methylation in the imprinted mouse Igf2 and H19 genes.
Development (Cambridge, England) - 1 Oct 1994
Feil R, Walter J, Allen N D, Reik W
Abstract excerpt
The Insulin-like growth factor 2 (Igf2) and H19 genes are reciprocally imprinted and closely linked. Igf2 encodes a fetal growth-factor and is predominantly expressed from the paternal allele, while H19 is expressed from the maternal allele and encodes a transcript which may downregulate cellular proliferation. One of the epigenetic modifications thought to be involved in parental imprinting is DNA methylation....
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