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Article

Establishment and maintenance of H19 imprinting in the germline and preimplantation embryo.

Cytogenetic and genome research - 1 Jan 2006

Reese K J, Bartolomei M S

Abstract excerpt

The mouse H19 and Igf2 genes are oppositely imprinted and share enhancers that reside 3' to the genes. The imprinted expression of these genes is coordinated by a 2-kb regulatory element, the differentially methylated domain (DMD), positioned between the two genes. The methylation status of this region determines the ability of the insulator factor CTCF to bind to its sites in the DMD. Deletions and mutations of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16575175
DOI: 10.1159/000090827

Genes

DMD
CTCF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Establishment and maintenance of H19 imprinting in the germline and preimplantation embryo.PMID 16575175Read ↗

Developmental profile of H19 differentially methylated domain (DMD) deletion alleles reveals multiple roles of the DMD in regulating allelic expression and DNA methylation at the imprinted H19/Igf2 locus.Semantic proximity Read ↗

Mechanisms of Igf2/H19 Imprinting: DNA Methylation, Chromatin and Long-Distance Gene RegulationSemantic proximity Read ↗

CTCF binding sites promote transcription initiation and prevent DNA methylation on the maternal allele at the imprinted H19/Igf2 locus.Semantic proximity Read ↗

Deletion of the H19 differentially methylated domain results in loss of imprinted expression of H19 and Igf2.Semantic proximity Read ↗

Dynamic readjustment of parental methylation patterns of the 5'-flank of the mouse H19 gene during in vitro organogenesis.Semantic proximity Read ↗

Analysis of sequence upstream of the endogenous H19 gene reveals elements both essential and dispensable for imprinting.Semantic proximity Read ↗

A paternal-specific methylation imprint marks the alleles of the mouse H19 gene.Semantic proximity Read ↗

Epigenetic mechanisms underlying the imprinting of the mouse H19 gene.Semantic proximity Read ↗

The human and mouse H19 imprinting control regions harbor an evolutionarily conserved silencer element that functions on transgenes in Drosophila.Semantic proximity Read ↗

Imprinted expression and methylation of the mouse H19 gene are conserved in extraembryonic lineages.Semantic proximity Read ↗

TheH19Differentially Methylated Region Marks the Parental Origin of a Heterologous Locus without Gametic DNA MethylationSemantic proximity Read ↗

H19 and Igf2 monoallelic expression is regulated in two distinct ways by a shared cis acting regulatory region upstream of H19.Semantic proximity Read ↗

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