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Article

A 5' 2-kilobase-pair region of the imprinted mouse H19 gene exhibits exclusive paternal methylation throughout development.

Molecular and cellular biology - 1 Aug 1997

Tremblay K D, Duran K L, Bartolomei M S

Abstract excerpt

The imprinted mouse H19 gene is hypermethylated on the inactive paternal allele in somatic tissues and sperm. Previous observations from a limited analysis have suggested that methylation of a few CpG dinucleotides in the region upstream from the start of transcription may be the mark that confers parental identity to the H19 alleles. Here we exploit bisulfite mutagenesis coupled with genomic sequencing to derive...

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Identifiers

PMID: 9234689
DOI: 10.1128/MCB.17.8.4322
PMCID: PMC232285

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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A 5' 2-kilobase-pair region of the imprinted mouse H19 gene exhibits exclusive paternal methylation throughout development.PMID 9234689Read ↗

Bisulfite sequencing in preimplantation embryos: DNA methylation profile of the upstream region of the mouse imprinted H19 gene.Semantic proximity Read ↗

Imprinted expression and methylation of the mouse H19 gene are conserved in extraembryonic lineages.Semantic proximity Read ↗

A paternal-specific methylation imprint marks the alleles of the mouse H19 gene.Semantic proximity Read ↗

Acquisition of the H19 methylation imprint occurs differentially on the parental alleles during spermatogenesis.Semantic proximity Read ↗

The H19 methylation imprint is erased and re-established differentially on the parental alleles during male germ cell development.Semantic proximity Read ↗

Temporal and spatial regulation of H19 imprinting in normal and uniparental mouse embryosSemantic proximity Read ↗

Deletion of the H19 differentially methylated domain results in loss of imprinted expression of H19 and Igf2.Semantic proximity Read ↗

Role for DNA methylation in genomic imprinting.Semantic proximity Read ↗

Developmental profile of H19 differentially methylated domain (DMD) deletion alleles reveals multiple roles of the DMD in regulating allelic expression and DNA methylation at the imprinted H19/Igf2 locus.Semantic proximity Read ↗

Mouse/human sequence divergence in a region with a paternal-specific methylation imprint at the human H19 locus.Semantic proximity Read ↗

Characterization of novel parent-specific epigenetic modifications upstream of the imprinted mouse H19 gene.Semantic proximity Read ↗

Parental allele-specific chromatin configuration in a boundary-imprinting-control element upstream of the mouse H19 gene.Semantic proximity Read ↗

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