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Article

Bisulfite sequencing in preimplantation embryos: DNA methylation profile of the upstream region of the mouse imprinted H19 gene.

Genomics - 15 Jul 1998

Warnecke P M, Mann J R, Frommer M, Clark S J

Abstract excerpt

In this study we describe a modification of the bisulfite genomic sequencing protocol that enables detection of methylation from as few as five diploid cells from preimplantation mouse embryos. We have used bisulfite genomic sequencing to study the methylation profile of the putative imprinting element upstream of the mouse H19 gene at several stages of embryonic development, including fertilized oocytes and...

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Identifiers

PMID: 9722940
DOI: 10.1006/geno.1998.5371

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Bisulfite sequencing in preimplantation embryos: DNA methylation profile of the upstream region of the mouse imprinted H19 gene.PMID 9722940Read ↗

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The H19 methylation imprint is erased and re-established differentially on the parental alleles during male germ cell development.Semantic proximity Read ↗

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A paternal-specific methylation imprint marks the alleles of the mouse H19 gene.Semantic proximity Read ↗

Conservation of DNA Methylation Programming Between Mouse and Human Gametes and Preimplantation EmbryosSemantic proximity Read ↗

Dynamic epigenomic landscapes during early lineage specification in mouse embryos.Semantic proximity Read ↗

Temporal and spatial regulation of H19 imprinting in normal and uniparental mouse embryosSemantic proximity Read ↗

Bisulfite sequencing and dinucleotide content analysis of 15 imprinted mouse differentially methylated regions (DMRs): paternally methylated DMRs contain less CpGs than maternally methylated DMRsSemantic proximity Read ↗

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