Article
Imprinted expression and methylation of the mouse H19 gene are conserved in extraembryonic lineages.
Developmental genetics - 1 Jan 1998
Davis T L, Tremblay K D, Bartolomei M S
Abstract excerpt
The imprinted H19 gene is hypomethylated on the active maternal allele and hypermethylated on the repressed paternal allele in the somatic tissues of mice and humans. We previously demonstrated that the paternal-specific methylation of a 2 kb region located between -2 and -4 kb relative to the start of transcription is maintained throughout murine development, and we thus propose that this region is crucial to...
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