Article
A paternal-specific methylation imprint marks the alleles of the mouse H19 gene.
Nature genetics - 1 Apr 1995
Tremblay K D, Saam J R, Ingram R S, Tilghman S M, Bartolomei M S
Abstract excerpt
Imprinting, the differential expression of the two alleles of a gene based on their parental origin, requires that the alleles be distinguished or marked. A candidate for the differentiating mark is DNA methylation. The maternally expressed H19 gene is hypermethylated on the inactive paternal allele in somatic tissues and sperm, but to serve as the mark that designates the imprint, differential methylation must...
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