A paternal-specific methylation imprint marks the alleles of the mouse H19 gene.

doi:10.1038/ng0495-407

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Article

A paternal-specific methylation imprint marks the alleles of the mouse H19 gene.

Nature genetics - 1 Apr 1995

Tremblay K D, Saam J R, Ingram R S, Tilghman S M, Bartolomei M S

Abstract excerpt

Imprinting, the differential expression of the two alleles of a gene based on their parental origin, requires that the alleles be distinguished or marked. A candidate for the differentiating mark is DNA methylation. The maternally expressed H19 gene is hypermethylated on the inactive paternal all...

Topics

Alleles
Animals
Base Sequence
Blastocyst
Crosses, Genetic
DNA
DNA Primers
Embryonic and Fetal Development
Female
Genomic Imprinting
Male
Methylation
Mice
Mice, Inbred C57BL
Molecular Sequence Data
Muridae
Oocytes
Paternity

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