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Article

Mapping quantitative trait loci for seizure response to a GABAA receptor inverse agonist in mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 May 1999

Gershenfeld H K, Neumann P E, Li X, St Jean P L, Paul S M

Abstract excerpt

To define the genetic contributions affecting individual differences in seizure threshold, a beta carboline [methyl-beta-carboline-3-carboxylate (beta-CCM)]-induced model of generalized seizures was genetically dissected in mice. beta-CCM is a GABAA receptor inverse agonist and convulsant. By measuring the latency to generalized seizures after beta-CCM administration to A/J and C57BL6/J mice and their progeny, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 10234005
PMCID: PMC6782732

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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