Article
Mapping murine loci for seizure response to kainic acid.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Mar 1997
Ferraro T N, Golden G T, Smith G G, Schork N J, St Jean P, Ballas C, Choi H, Berrettini W H
Abstract excerpt
Mature DBA/2J (D2) mice are very sensitive to seizures induced by various chemical and physical stimuli, whereas C57BL/6J (B6) mice are relatively seizure resistant. We have conducted a genome-wide search for quantitative trait loci (QTLs) influencing the differential sensitivity of these strains...
Topics
- Animals
- Chromosome Mapping
- Crosses, Genetic
- Drug Resistance
- Excitatory Amino Acid Agonists
- Female
- Genetic Linkage
- Genetic Markers
- Genotype
- Kainic Acid
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Inbred DBA
