Article
Analysis of a quantitative trait locus for seizure susceptibility in mice using bacterial artificial chromosome-mediated gene transfer.
Epilepsia - 1 Sept 2007
Ferraro Thomas N, Golden Gregory T, Dahl John P, Smith George G, Schwebel Candice L, MacDonald Ross, Lohoff Falk W, Berrettini Wade H, Buono Russell J
Abstract excerpt
PURPOSE: Previous quantitative trait loci (QTL) mapping studies from our laboratory identified a 6.6 Mb segment of distal chromosome 1 that contains a gene (or genes) having a strong influence on the difference in seizure susceptibility between C57BL/6 (B6) and DBA/2 (D2) mice. A gene transfer strategy involving a bacterial artificial chromosome (BAC) DNA construct that contains several candidate genes from the...
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