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Article

Collaborative Cross mice reveal extreme epilepsy phenotypes and genetic loci for seizure susceptibility.

Epilepsia - 1 Sept 2020

Gu Bin, Shorter John R, Williams Lucy H, Bell Timothy A, Hock Pablo, Dalton Katherine A, Pan Yiyun, Miller Darla R, Shaw Ginger D, Philpot Benjamin D, Pardo-Manuel de Villena Fernando

Abstract excerpt

OBJECTIVE: Animal studies remain essential for understanding mechanisms of epilepsy and identifying new therapeutic targets. However, existing animal models of epilepsy do not reflect the high level of genetic diversity found in the human population. The Collaborative Cross (CC) population is a genetically diverse recombinant inbred panel of mice. The CC offers large genotypic and phenotypic diversity, inbred...

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Identifiers

PMID: 32852103
DOI: 10.1111/epi.16617
PMCID: PMC8011945

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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