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Article

Mapping a mouse limbic seizure susceptibility locus on chromosome 10.

Epilepsia - 1 Nov 2011

Winawer Melodie R, Gildersleeve Sandra S, Phillips Austin G, Rabinowitz Daniel, Palmer Abraham A

Abstract excerpt

PURPOSE: Mapping seizure susceptibility loci in mice provides a framework for identifying potentially novel candidate genes for human epilepsy. Using C57BL/6J × A/J chromosome substitution strains (CSS), we previously identified a locus on mouse chromosome 10 (Ch10) conferring susceptibility to pilocarpine, a muscarinic cholinergic agonist that models human temporal lobe epilepsy by inducing initial limbic...

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Share to Chromosome Mapping
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred C57BL

Share to Polymorphism, Single Nucleotide

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Source

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Identifiers

PMID: 21906048
DOI: 10.1111/j.1528-1167.2011.03256.x
PMCID: PMC3346290

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