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Article

Quantitative genetic study of maximal electroshock seizure threshold in mice: evidence for a major seizure susceptibility locus on distal chromosome 1.

Genomics - 1 Jul 2001

Ferraro T N, Golden G T, Smith G G, Longman R L, Snyder R L, DeMuth D, Szpilzak I, Mulholland N, Eng E, Lohoff F W, Buono R J, Berrettini W H

Abstract excerpt

We conducted a quantitative trait locus (QTL) mapping study to dissect the multifactorial nature of maximal electroshock seizure threshold (MEST) in C57BL/6 (B6) and DBA/2 (D2) mice. MEST determination involved a standard paradigm in which 8- to 12-week-old mice received one shock per day with a daily incremental increase in electrical current until a maximal seizure (tonic hindlimb extension) was induced. Mean...

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Source

Identifiers

PMID: 11472065
DOI: 10.1006/geno.2001.6577

Genes

MEST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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