Article
Fine mapping of a seizure susceptibility locus on mouse Chromosome 1: nomination of Kcnj10 as a causative gene.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Apr 2004
Ferraro Thomas N, Golden Gregory T, Smith George G, Martin James F, Lohoff Falk W, Gieringer Tracy A, Zamboni Deborah, Schwebel Candice L, Press Danielle M, Kratzer Stephanie O, Zhao Hongyu, Berrettini Wade H, Buono Russell J
Abstract excerpt
Previous quantitative trait loci (QTL) mapping studies document that the distal region of mouse Chromosome (Chr) 1 contains a gene(s) that is in large part responsible for the difference in seizure susceptibility between C57BL/6 (B6) (relatively seizure-resistant) and DBA/2 (D2) (relatively seizure-sensitive) mice. We now confirm this seizure-related QTL ( Szs1) using reciprocal, interval-specific congenic...
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