Article
Effect of ionizing radiation on wild-type and mutant mouse leukemia L1210 cells.
Oncology research - 1 Jan 1998
He A W, Cory J G
Abstract excerpt
Wild-type (WT) mouse leukemia L1210 cells express steady-state levels of p53 mRNA and protein. However, the p53 expressed by the wild-type L1210 cells was found to be a mutant form of p53 (relative to normal mouse fibroblast p53 sequence) having a point mutation in the DNA binding domain of p53. A deoxyadenosine-resistant L1210 cell line (Y8) derived from the parental WT cells had previously been shown to lack...
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