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Article

Abrogation of p53 Function Affects gadd Gene Responses to DNA Base-Damaging Agents and Starvation

1 Oct 1996

Abstract excerpt

The tumor suppressor p53 is required for induction of its downstream effector genes such as GADD45 and CIP1/WAF1 by ionizing radiation (IR). This response is probably mediated through defined p53 binding sites located in the promoter of CIP1/WAF1 and in the third intron of GADD45. In contrast, the gadd gene stress response to base-damaging agents, such as methylmethane sulfonate (MMS) or UV radiation, or medium...

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Identifiers

PMID: 8892753
DOI: 10.1089/dna.1996.15.805

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Source receipt: pubmed, retrieved 7 Sept 2026.

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