Human lymphoblastoid cell lines expressing mutant p53 exhibit decreased sensitivity to cisplatin-induced cytotoxicity.

doi:10.1038/sj.onc.1202147

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Article

Human lymphoblastoid cell lines expressing mutant p53 exhibit decreased sensitivity to cisplatin-induced cytotoxicity.

Oncogene - 5 Nov 1998

Piovesan B, Pennell N, Berinstein N L

Abstract excerpt

Human lymphoblastoid cells were transfected with expression vectors containing p53 cDNA mutated at either codon 135 or 246. The cells were subjected to cisplatin treatment or gamma-radiation and observed for changes in the cell cycle arrest and apoptosis. We found that compared to the parental ce...

Topics

Antineoplastic Agents
Apoptosis
B-Lymphocytes
Cell Line
Cisplatin
Cyclin-Dependent Kinase Inhibitor p21
Cyclins
G1 Phase
Gamma Rays
Humans
Lymphoma, Large B-Cell, Diffuse
Mutation
Neoplasm Proteins
Nuclear Proteins
Poly(ADP-ribose) Polymerases
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-bcl-2
Proto-Oncogene Proteins c-mdm2

Source

Open in PubMed

Identifiers

PMID: 9811465
DOI: 10.1038/sj.onc.1202147

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9811465-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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