Article
An abnormality in the p53 pathway following gamma-irradiation in many wild-type p53 human melanoma lines.
Cancer research - 15 Feb 1996
Bae I, Smith M L, Sheikh M S, Zhan Q, Scudiero D A, Friend S H, O'Connor P M, Fornace A J
Abstract excerpt
DNA-damaging agents such as ionizing radiation (IR) activate the tumor suppressor p53, and, in turn, p53 transactivates a number of downstream effector genes such as GADD45, CIP1/WAF1, and MDM2. The induction of these downstream genes following IR appears to be strictly dependent upon the presenc...
Topics
- Base Sequence
- Cell Line
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
- DNA Damage
- DNA Primers
- DNA, Neoplasm
- Female
- Flow Cytometry
- Gamma Rays
- Genes, p53
- Genotype
- Humans
- Intracellular Signaling Peptides and Proteins
- Male
- Melanoma
- Molecular Sequence Data
- Neoplasm Proteins