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Article

An abnormality in the p53 pathway following gamma-irradiation in many wild-type p53 human melanoma lines.

Cancer research - 15 Feb 1996

Bae I, Smith M L, Sheikh M S, Zhan Q, Scudiero D A, Friend S H, O'Connor P M, Fornace A J

Abstract excerpt

DNA-damaging agents such as ionizing radiation (IR) activate the tumor suppressor p53, and, in turn, p53 transactivates a number of downstream effector genes such as GADD45, CIP1/WAF1, and MDM2. The induction of these downstream genes following IR appears to be strictly dependent upon the presence of wild-type functional p53 known to evoke G1 arrest. In this study, we characterized 56 cell lines from 9 different...

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Source

Identifiers

PMID: 8631022

Genes

MDM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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