Article
Diminished capacity for p53 in mediating a radiation-induced G1 arrest in established human tumor cell lines.
Oncogene - 2 Nov 1995
Li C Y, Nagasawa H, Dahlberg W K, Little J B
Abstract excerpt
It has been reported that the p53 gene mediates an ionizing radiation-induced G1 arrest in mammalian cells. To further characterize this important phenomenon, a panel of seven human diploid fibroblast cell strains and 14 human tumor cell lines from a variety of sources with both wild-type and mutant p53 status were assayed for their susceptibility to G1 arrest after gamma-ray irradiation by a continuous labeling...
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