Article
Diminished capacity for p53 in mediating a radiation-induced G1 arrest in established human tumor cell lines.
Oncogene - 2 Nov 1995
Li C Y, Nagasawa H, Dahlberg W K, Little J B
Abstract excerpt
It has been reported that the p53 gene mediates an ionizing radiation-induced G1 arrest in mammalian cells. To further characterize this important phenomenon, a panel of seven human diploid fibroblast cell strains and 14 human tumor cell lines from a variety of sources with both wild-type and mut...
Topics
- Ataxia Telangiectasia
- Base Sequence
- Blotting, Western
- Cell Cycle
- Cell Line
- Cell Survival
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
- DNA Primers
- DNA Replication
- Enzyme Inhibitors
- Fibroblasts
- G1 Phase
- Gamma Rays
- Gene Expression
- Genes, p53
- Humans
- Molecular Sequence Data